- Chairman, Roche Holding Ltd - 2008 to Present
- Chairman & Chief Executive Officer, Roche Group - 2001 to 2008
- Chief Executive Officer, Roche Group - 1998 to 2001
- Chief Operating Officer, F. Hoffmann-La Roche Ltd - 1996 to 1998
- Head of Pharmaceuticals, F. Hoffmann-La Roche Ltd - 1995 to 1996
- Other Directorship: Diageo plc (Chairman)
- Previous Directorships within the last five years: Allianz SE
- Other Activities: Friends of Phelophepa Foundation (Chairman), INSEAD (Chairman), International Centre for Missing and Exploited Children (Chairman), Member of the European Round Table of Industrialists (ERT), Salzburg University (Member of the Board) and Jacobs Holding AG (Member of the Board)